From genotype to outcomes: Real-world evidence in glomerular diseases

This presentation highlights real-world evidence from RenasightIQ to demonstrate how integrated clinical and genetic data are transforming risk stratification and treatment optimization in glomerular disease. With focused insights from genetic ancestry, we will examine how genetic drivers influence disease trajectory and therapeutic response. The session will also review real-world treatment effects of steroids/immunosuppression, ACE inhibitors/ARBs, and SGLT2 inhibitors. Together, these findings underscore how precision medicine approaches can improve prognostic clarity, guide treatment decisions, and drive better patient outcomes.

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Ronen Schneider

Medical Director of Renal Genetics, Natera

Dr. Ronen Schneider is a clinician-scientist with expertise in the genetic mechanisms of nephrotic syndrome. He trained at Hadassah Hospital in Jerusalem, Israel, where he became an Attending Nephrologist before moving to the U.S. in 2016 for a postdoctoral research fellowship at Boston Children's Hospital (BCH). He most recently had dual roles as an Associate Physician in the Renal Division at Brigham and Women’s Hospital and a Principal Investigator at BCH. His research has focused on the molecular and clinical genetics of chronic kidney disease, leading to the discovery of novel monogenic causes of steroid-resistant nephrotic syndrome. He has co-authored over 40 peer-reviewed publications and led innovative work on gene therapy for glomerular diseases. Dr. Ronen has been actively involved in clinical nephrology, including co-directing the Renal Genetics and PKD Clinic at BWH. Currently, he is the Medical Director of renal genetics at Natera.

Moderator

Dinah Clark

Director of Medical Education, Natera

Dinah Clark has been a genetic counselor at Natera since 2011 and worked at The Children's Hospital of Philadelphia in the 10 years prior. Natera entered the organ health space in 2019, and since then, she has focused on renal genetics, managing clinical and scientific content that supports novel discoveries and pharma partnerships. Dinah graduated from Rutgers University with a BS in Biology and Psychology and received a Master's Degree in Genetic Counseling from Arcadia University.